The purpose of this position is to provide support to Research & Development activities according to the Government of Canada Science & Technology priorities, CANDU Owners Group, commercial and internal research activities investigating the biological effects of ionizing radiation as it relates to radiological protection and nuclear medicine. The incumbent will become a part of a vibrant team of researchers who carry out and support various research areas, such as cancer biology, mutagenesis, epigenetics and immunology - in the context of radiobiology. The incumbent would report to a senior project scientist and/or directly to the Branch Manager.
The recruited candidate will have the overall responsibility for the day-to-day supervision and management of research activities that have been approved and assigned to him/her. This includes, but is not limited to the following:
Supporting research and development activities that align with CNL and Health Program strategic direction and stakeholder input
Supporting existing research projects and proposing new projects
Managing research projects for all stakeholders, including customers
Actively participating and contributing to team initiatives at company, program, branch and section levels
Conducting biological research to improve understanding of how mammalian cells, tissues and organisms respond to ionizing radiation.Specifically, priority will be given to immunological/inflammatory responses and links to epigenetic DNA methylation and transcriptomics in the context of cancer development and therapy.Other research areas include using gene editing techniques (such as CRISPR-cas9) to identify intrinsic determinants of individual radio-sensitivity and radio-resistance.Both external and internal irradiations will be examined, with a potential involvement of metal metabolism.
Ensuring the continued progress in specific projects involving radiation-induced cataracts and radiation therapy and adaptive immunity.
Working with and directing technical staff for in vitro laboratory experiments with specialized cell lines.
Exposing cell lines to gamma radiation where required
Supervising experiments using a hypoxia chamber
Analyzing and interpreting experimental data, using general statistics and graphing software as well as specialized analysis packages
Preparing manuscripts for publication in peer-reviewed journals, as well as research reports for internal or external customers
Preparing and presenting talks and poster presentations at internal and external conferences, seminars and meetings
Attending and participating in project meetings to organize experimental work.
Supervising the day-to-day activities as well as providing technical guidance, on-the-job training and leadership for technical staff and students
Producing administrative, progress, scientific and technical reports
Working with Business Development to ensure maximum impact is achieved for research projects
Maintaining approved external communications with partners, collaborators, clinicians, customers and other parties with respect to research projects, results and applications
Ensuring that all activities are carried out with due diligence relative to established Quality Assurance/Quality Control requirements and Standard Operating Procedures, applicable environmental and safety regulations and requirements (industrial, biological, radiological), and company policies and procedures (including relevant labour contracts
A PhD in a Biology/Immunology discipline, from a university of recognized standing
Experience in one or more of the following fields (in order of priority) is preferred: Radiobiology, immunology, cell biology, molecular biology, mouse models of cancer, cancer biology, epigenetics
Experience with large in vivo studies, including mouse handling, planning and implementation of sacrifices and tissue handling and processing is preferred
Experience utilizing in vitro and in vivo systems, collecting tissues for end-point measurements and running various cellular, molecular and biochemical assays using a wide range of general and specialized laboratory equipment (e.g. hypoxia chamber, flow cytometer, cytokine assay by Bioplex, histology, DNA/RNA/protein analysis, confocal microscopy)
Strong theoretical knowledge and practical skills/experience in mouse cancer models, mammalian immune responses, metabolism of metals, mammalian microbiome, analyses of whole-genome DNA data - as demonstrated by peer-reviewed publications, conference abstracts, research reports or fellowships
Expertise in design and execution of in vivo cancer models to look at tumorigenesis and underlying molecular mechanisms
Experience with Gene Editing Techniques such as CRISPR-Cas9 preferred
Expertise in microfluidics and 3-D printing is an asset
Expertise in low-dose radiation (LDR) research, including design and implementation of LDR projects and experiments
Demonstrated ability to publish his/her research results as lead or senior author in peer-reviewed scientific literature
Effective English oral communication skills for presenting results of his/her research to both scientific and lay (non-professional) audiences as demonstrated by a record of conference, workshop and meeting presentations
Excellent interpersonal skills and be effective working in diverse team as well as the ability to work independently
Experience in training and supervising technologists and students preferred
Knowledge of software such as Excel, Word, Power Point, Sigma Plot, End Note, Mendeley